Tumour necrosis factor alpha: a key regulator of adipose tissue mass

NEW PERSPECTIVES ON ENDOCRINE SIGNALLING Tumour necrosis factor : a key regulator of adipose tissue mass

In addition to its established role in the immune system, tumour necrosis factor (TNF ) exerts complex regulatory actions on adipose tissue. TNF is produced in and secreted by the adipocyte and thus is in a position to exert a paracrine and/or autocrine role within adipose tissue. TNF affects many aspects of adipocyte function, from adipocyte development to lipid metabolism. Bringing together a...

The Effect of Aerobic Training on Tumor Necrosis Factor alpha, Hypoxia-Inducible Factor-1 alpha & Vascular Endothelial Growth Factor Gene Expression in Cardiac Tissue of Diabetic Rats

Objective: The goal of this research was to determine the influence of 4 weeks aerobic training on gene expression of tumor necrosis factor alpha (TNF-α), hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) in the cardiac tissue of diabetic rats. Materials and Methods: In an experimental study, 30 male wistar rats were partitioned into three groups (n=10), d...

A metal-based tumour necrosis factor-alpha converting enzyme inhibitor.

We report herein a novel iridium(III) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells.

Post-transcriptional regulation of tumour necrosis factor alpha production.

Tumour necrosis factor á (TNFá) is a proinflammatory cytokine produced by activated macrophages, lymphocytes and other cells. The production of TNFá is under transcriptional and post-transcriptional control. Post-transcriptional control of TNFá expression is achieved by regulating translational initiation, mRNA stability, and polyadenylation. 7 10 An adenine and uridine (AU)-rich element (ARE) ...

Tumour necrosis factor alpha blockade and the risk of vasculitis.